University of Cambridge > Talks.cam > Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer > Duplicating the Human genome: The Origin Recognition Complex et al

Duplicating the Human genome: The Origin Recognition Complex et al

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The entire process of duplication of the cell’s genetic material is started by the ATP -dependent Origin Recognition Complex (ORC) binding to chromosomes and then promoting the establishment of pre-Replicative Complexes (pre-RCs) at numerous sites within the genome. Following pre-RC assembly, multiple protein kinases and other regulatory processes control the recruitment of many replication proteins that initiate DNA synthesis. In the process the pre-RCs are destroyed. Stillman will discuss the biochemical steps in assembly of pre-RCs and present data on how the process of initiation of DNA replication is controlled by Cyclin-dependent protein kinases (CDKs), the Dbf4-Cdc7 protein kinase (DDK) and cell proliferation regulators such as the retinoblastoma protein Rb. Inherited genetic effects in genes encoding pre-RC proteins such as ORC cause Meier-Gorlin Syndrome, a disorder resulting in short stature and microcephaly. ORC mutations affect both DNA replication and centrosome duplication, contributing to the diverse phenotypes in such individuals.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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