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The impact of cohesin on the regulation of gene expression and the organization of chromatin

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If you have a question about this talk, please contact Kate Davenport.

Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and post-replicative DNA repair. Growing evidence from human genetics and model organisms links cohesin to the formation of long-range chromosomal interactions and to the regulation of gene expression in association with CTCF , mediator, or tissue-specific transcription factors. We have taken genetic approaches to determine the impact of cohesin on developmentally regulated gene expression and the organization of chromatin in non-dividing mammalian cells. Since gene dosage reductions in the cohesin loading factor Nipbl are the leading cause of Cornelia de Lange syndrome, we have also investigated the transcriptional and post-transcriptional regulation of Nipbl expression.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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