|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
The role of telomeres and telomerase in stem cell biology, cancer and ageing
If you have a question about this talk, please contact Kate Davenport.
Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized proteins. The length of telomere repeats and the integrity of telomere-binding proteins are both important for telomere protection. Furthermore, telomere length and integrity are regulated by a number of epigenetic modifications, thus pointing to a higher-order control of telomere function. We have recently discovered that telomeres are transcribed generating, long, non-coding RNAs, which remain associated to the telomeric chromatin and are likely to have an important role in the regulation of telomeres. We have shown in the past that telomere length and the catalytic component of telomerase, Tert, are critical determinants for the mobilization of stem cells. The effects of telomerase and telomere length on stem cell behavior anticipate the premature aging and cancer phenotypes of telomerase mutant mice. More recently, we have used this information to generate long-lived mice. Shelterin is the major protein complex bound to mammalian telomeres, however, its potential relevance for cancer and aging was not addressed to date. I will report on mice conditionally deleted for the shelterin proteins TRF1 , TPP1 and RAP1 . The study of these mice demonstrate that dysfunction of a telomere-associated protein is sufficient to produce severe telomeric damage in the absence of telomere shortening, resulting into premature tissue degeneration, acquisition of chromosomal aberrations and initiation of neoplastic lesions. These new mouse models, together with the telomerase-deficient mouse model, are valuable tools to understand human pathologies produced by telomere dysfunction (“telopathies”).
This talk is part of the Cancer Research UK Cambridge Institute Seminars in Cancer series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsmathematics Rasch Users Group Bert's list
Other talksFrom conic sections to toric sections: experiments with Computer Algebra System leading to curriculum changes Building Business in the Sunshine Excavation: Living with the Ancient Romans: Past and Present in Eighteenth-Century Encounters with Herculaneum and Pompeii Anharmonic phonon properties: electron-phonon coupling and stress Fireworks Lecture - Spectacular Chemistry Demonstration “The Impact of Impact: The future of science funding”