“Development and Manufacture of an Affinity Filter for the Removal of vCJD from Blood and Blood-Derived Products”
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If you have a question about this talk, please contact Elena Gonzalez.
Steve will talk about the challenges encountered during the development and
manufacture of a medical device for the capture and removal of infectious prions
from donated blood. The consumption of BSE contaminated beef products in the late
1980’s and early 1990’s gave rise to a new human pathogenic disease – variant
Creutzfeldt-Jacob Disease (vCJD). This fatal brain wasting disease has a long
incubation time and can be transferred unknowingly from an infected, but outwardly
healthy person, to an uninfected person by blood transfusion.
The solution to this threat was to develop a unique blood filter, P-CAPT® , a sterile,
single-use medical device which incorporates novel affinity ligand technology and
novel membrane technology. This has undergone extensive safety and clinical
studies and is now in routine use at various locations around the world to improve
blood safety. Materials design and biochemical engineering were employed in the
development of this product . The importance of a multidisciplinary team approach to
problem solving will also be discussed.
This talk is part of the CEB Alumni Speaker Series series.
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