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sRNA-directed heterochromatin formation in Chlamydomonas?

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Chromatin-mediated transcriptional silencing is a fundamental process used to regulate numerous DNA -dependent processes including regulation of gene expression, and preventing aberrant expression of transposons. It is also an important consideration in the generation of transgenic organisms. I will describe the patterns of DNA methylation and chromatin modifications in Chlamydomonas, and a forward genetic screen aimed to identify components involved in small RNA targeted transcriptional silencing. I will also discuss the potential involvement of a SIR2 -like histone deacetylase in this process.

This talk is part of the Plant Sciences Research Seminars series.

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