University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > Species-differences in pathogen recognition and their consequences for Vaccines

Species-differences in pathogen recognition and their consequences for Vaccines

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Toll-Like Receptors (TLRs) are a family of pattern recognition receptors that are an important link between innate and adaptive immunity. Many vaccines incorporate ligands for TLRs as an adjuvant and are developed in rodent models, with the resulting data transferred to other species. Vaccine features can be improved markedly by emphasising the biological relevance when evaluating other animal models for host-pathogen interaction and by taking greater advantage of the unique experimental opportunities that are offered by large animal, non-rodent models. In the present talk, I will summarise our current knowledge of species-specific TLR responses and briefly discuss that vaccine efficacy in relevant host species might be improved by considering the species-specific TLR responses.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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