University of Cambridge > Talks.cam > Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer > Understanding Mechanisms of Microenvironment-Mediated Therapy Resistance

Understanding Mechanisms of Microenvironment-Mediated Therapy Resistance

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  • UserProfessor Michael Hemann, Koch Institute for Integrative Research at MIT World_link
  • ClockFriday 13 December 2024, 13:00-14:00
  • HouseCRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

Many human cancers fail to respond to DNA damaging chemotherapy, and cancers that initially respond frequently acquire drug resistance and relapse. This process of tumor relapse is particularly confounding, as patients can be in remission for years following treatment prior to the reemergence of a cancer. Our group has used in vivo genetic screens to show that select microenvironments can underlie resistance to chemotherapy and cell-based immunotherapy and persistence of microenvironment-specific residual disease. Our findings highlight potential avenues for therapeutic synergy by targeting pathways involved in context-dependent drug resistance.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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