Senescent secretome shenanigans: Differential therapeutic benefit for breast cancer dictated by distinct extracellular vesicle-mediated inflammatory response

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• Dr Karen Crasta, Principal Investigator at the National University of Singapore, Centre for Healthy Longevity and Department of Physiology.
• Thursday 17 October 2024, 13:00-14:00
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

Triple-negative breast cancers, associated with poor prognosis and high tumour recurrence, are often-treated with taxanes in first-line treatment regimens. However, acquired disease resistance often sets in, hampering clinical efficacy. Senescent cells represent a population of residual disease that is highly secretory and drives cancer relapse. Although it is known that therapy-induced senescence can contribute to therapy resistance and cancer relapse via its secretome, the underlying cellular and molecular mechanisms are not fully understood. In this talk, I will discuss a recent study which uncovered an unexpected role for small extracellular vesicles within the senescent tumour cell-derived secretome where they confer critical impact as discrete entities which mediate distinct anti-tumourigenic properties and inflammatory response.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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