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CATEGORIES:Cancer Research UK Cambridge Institute (CRUK CI) S
 eminars in Cancer
SUMMARY:Senescent secretome shenanigans:  Differential the
 rapeutic benefit for breast cancer dictated by dis
 tinct extracellular vesicle-mediated inflammatory 
 response - Dr Karen Crasta\, Principal Investigato
 r at the National University of Singapore\, Centre
  for Healthy Longevity and Department of Physiolog
 y. 
DTSTART;TZID=Europe/London:20241017T130000
DTEND;TZID=Europe/London:20241017T140000
UID:TALK210511AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/210511
DESCRIPTION:Triple-negative breast cancers\, associated with p
 oor prognosis and high tumour recurrence\, are oft
 en-treated with taxanes in first-line treatment re
 gimens. However\, acquired disease resistance ofte
 n sets in\, hampering clinical efficacy. Senescent
  cells represent a population of residual disease 
 that is highly secretory and drives cancer relapse
 . Although it is known that therapy-induced senesc
 ence can contribute to therapy resistance and canc
 er relapse via its secretome\, the underlying cell
 ular and molecular mechanisms are not fully unders
 tood. In this talk\, I will discuss a recent study
  which uncovered an unexpected role for small extr
 acellular vesicles within the senescent tumour cel
 l-derived secretome where they confer critical imp
 act as discrete entities which mediate distinct an
 ti-tumourigenic properties and inflammatory respon
 se.
LOCATION:CRUK CI Lecture Theatre
CONTACT:Kate Davenport
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