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Human lung organoid models of lung development and disease

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Organoids derived from primary human tissues retain key functional characteristics of the tissue of interest and have the potential to improve in vitro assays used for disease modelling and drug development. However, the burgeoning CRISPR toolkits have not yet been widely applied to human organoids. We have developed efficient methodologies for the use of CRISPR techniques in primary human embryonic lung organoids. These will be widely adaptable to other human organoid systems and include homology directed repair, CRISP Ri, CRISP Ra and drop-out screens. This talk will illustrate how we have applied these systems to develop new human lung organoid models for fundamental developmental biology and disease research.

This talk is part of the Foster Talks series.

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