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Variability and Robustness in Neuronal Networks

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If you have a question about this talk, please contact stefan pulver.

Faculty host: Michael Bate, Department of Zoology

Neuronal oscillators, especially the central pattern generator circuits that control rhythmic behaviors such as breathing, need to function reliably throughout life despite ongoing turnover of their molecular components and other perturbations. How is this stability achieved? I will discuss recent results that show how parameter non-uniqueness, membrane conductance co-regulation, and activity-dependent homeostatic regulation through negative feedback loops act together to ensure reliable neuronal network function. My presentation will highlight how fruitful interactions between electrophysiology experiments and numerical modeling can advance our understanding of complex system dynamics at the intersection of physics and biology.

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