Functional imaging in stroke

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• Jean-Claude Baron Department of Clinical Neurosciences, University of Cambridge, R3 Neurosciences Addenbrooke's Hospital, Cambridge UK
• Wednesday 01 April 2009, 14:30-15:15
• Cripps Court, Magdalene College.

If you have a question about this talk, please contact Anna Di Pietro.

In people surviving from ischaemic stroke, recovery of function is almost consistently observed. Rapid recovery can take place In the first few days, while subsequently recovery slows down but can continue for months and even years. However, the temporal pattern and extent of recovery is highly variable from subject to subject. Understanding the mechanisms underlying this individual variability would help design improved therapy to speed up recovery and/or enhance final outcome. Functional imaging in patients, and parallel animal studies, has led to major advances in understanding the pathophysiological bases of recovery from stroke. In stroke affecting the cortex, functional imaging has shown that reperfusion of the ischaemic penumbra explains most of the early recovery, but also appears to sustain a large part of, subsequent clinical recovery by allowing preserved peri-infarct neurons to compensate for the damaged area, perhaps via unmasking of normally “silent” representations. After pure sub-cortical stroke, adaptation of overlying cortical areas to deafferentation has been documented, and shown to underlie clinical recovery. In addition, redistribution of function and reorganisation of remote functional networks, including contralesional areas, has also been documented after both cortical and subcortical strokes. Illustration of these mechanisms, and results from studies currently underway in the lab addressing e.g. tapping regularity, mirror movements, motor imagery and analysis of connectivity, will be presented.

This talk is part of the Spring School 2009 - "Regeneration and Plasticity of Neural Circuits" series.

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