University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > The role of the KCC transporters in epithelial cancers: evidence for involvement in cell migration, proliferation and epithelial-mesenchymal transition

The role of the KCC transporters in epithelial cancers: evidence for involvement in cell migration, proliferation and epithelial-mesenchymal transition

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The KCC family of transporters mediate Cl-dependent K loss from cells, and were originally identified principally for their role in cell volume regulation. The neuronal form KCC2 has also been shown to play an important role in neuronal development, setting intracellular Cl levels and GABA dependent inhibition. We have shown that KCC3 and KCC4 isoforms are markedly upregulated in human cancer cells, and affect not only ion transport, but invasion, growth and EMT . Besides an effect linked to intracellular Cl levels (presumably via Cl-dependent kinases) direct effects of the KCC proteins on trafficking and expression of adhesion molecules can be shown. These transporters may represent an important diagnostic correlate for tumour malignancy and cancer growth.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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