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Computational Morphodynamics - a quantitative description of multicellular development

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Biological organisms robustly develop into shapes with specified functionality. The plant shoot harbours a stem cell niche that stays throughout the life of the plant allowing for aerial organs to continuously develop in symmetric patterns. Since cell migration is not present this requires a balance between cell differentiation and morphogenesis driven by heterogeneous and anisotropic growth. In this presentation, I will discuss how we use live imaging of the development at cellular resolution and theoretical and computational models to improve our quantitative understanding of the complex dynamics at the plant shoot. We aim to elucidate the molecular and mechanical mechanisms driving the process and find design principles for how multicellular development can robustly be regulated. In addition, I will discuss how environmental factors can alter development and stem cell regulation in the plant shoot.

This talk is part of the Computational and Systems Biology series.

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