In search of the molecules of memory - ANNUAL LECTURE

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• Roger Nicoll, University of California San Francisco
• Monday 18 November 2019, 16:30-18:00
• Main Physiology Lecture Theatre, Department of Physiology, Development and Neuroscience, Physiology Building, Downing Site.

If you have a question about this talk, please contact Marisa Parsonage.

I will begin by introducing the problem of memory storage in the face of molecular turnover. I will then introduce long-term potentiation (LTP) and the role of calcium/CaMKII in this phenomenon. I will show that calcium and CaMKII are both necessary and sufficient for the induction of LTP . Much of the talk will focus on CaMKII and the maintenance of LTP (memory), which remains most contentious. Physiological evidence will be presented indicating that CaMKII fulfills most of the criteria necessary for its role in information storage.

This talk is part of the Adrian Seminars in Neuroscience series.

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