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CRISPR gene-drive and the war against malaria – the evolutionary ABCs

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If you have a question about this talk, please contact Agnes Bolinska.

CRISPR is a new technology, but it mimics a process in nature that has been known for about 80 years, meiotic drive. In this talk, I’ll explain some of the basic evolutionary principles that allows a driving gene to increase in frequency in a population even when it harms the individuals that house it. I’ll also discuss two strategies that are now being pursued for using CRISPR gene drives to eradicate malaria. One involves driving to extinction the mosquitoes that spread malaria to humans; the other involves modifying the immune systems of those mosquitoes so that they are less able to spread malaria.

This talk is part of the Departmental Seminars in History and Philosophy of Science series.

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