Sensing enhanced by DNA nanotech

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• Prof. Philip Tinnefeld, Ludwig Maximilians-Universität München
• Friday 08 March 2019, 16:00-17:00
• Ryle Seminar Room, Cavendish Laboratory.

If you have a question about this talk, please contact Lorenzo Di Michele.

In recent years, DNA nanotechnology has matured to enable robust production of complex nanostructures and hybrid materials. We have combined DNA nanotechnology with sensitive optical detection to create functional single-molecule devices that enable new applications in single-molecule biosensing and superresolution microscopy. Starting with superresolution nanorulers and brightness reference samples we determined the resolving power of superresolution microscopes and evaluated the sensitivity of smartphone cameras. To improve the sensitivity, we created DNA origami optical antennas for metal enhanced fluorescence. The unique ability of our DNA origami nanoantennas to place molecular assays specifically in the plasmonic hotspot is used for detecting Zika-virus and antibiotic resistance related nucleic acids. Furthermore, DNA origamis are used in biophysical assays to work at locally increased concentrations, to apply forces as well as to sense further physical parameters.

This talk is part of the Assembly and Function of Complex Systems series.

This talk is included in these lists:

• All Cavendish Laboratory Seminars
• Assembly and Function of Complex Systems
• Centre for Health Leadership and Enterprise
• Efficient and intuitive modelling of electromagnetic nanoresonators and complex metasurfaces
• Featured lists
• ME Seminar
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• Ryle Seminar Room, Cavendish Laboratory
• School of Physical Sciences
• Thin Film Magnetic Talks

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