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Discovering the gene networks that regulate hunger

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Abstract: Obesity and its co-morbidities are an emerging public health concern. The detailed mechanistic understanding of energy balance and the development of obesity is currently incomplete. The Genetics of Obesity Study (GOOS) recruited thousands of individuals with early-onset extreme childhood obesity. This study led to the identification of rare genetic variants affecting key processes in the hypothalamus, a part of the brain involved in weight regulation and energy balance. To gain further insights our current work encompasses the genetics of severe obesity and the genetics of thinness. We combine large genomic data sets from different populations and platforms with detailed clinical information related to thinness and severe obesity to discover new pathways involved in weight regulation and associated diseases.

This talk is part of the Computational and Systems Biology series.

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