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New trends in cardiac valve and cardiovascular modelling

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If you have a question about this talk, please contact Katja Kivinen.

Host: Zhongzhao Teng

Our Center has pioneered the development and application of morphologically-driven constitutive models for heart valve tissues. Our current work focuses on mitral valve (MV) repair, since recent long-term studies have indicated that excessive tissue stress and the resulting strain-induced tissue failure are important etiologic factors leading to the recurrence of significant MR after repair.

In the present work, we have developed a high-fidelity computational framework, incorporating detailed collagen fiber architecture, accurate constitutive models for soft valve tissues, and micro-anatomically accurate valvular geometry, for simulations of functional mitral valves which allows us to investigate the organ-level mechanical responses due to physiological loadings. This computational tool also provides a means, with some extension in the future, to help the understanding of the connection between the repair-induced altered stresses/strains and valve functions, and ultimately to aid in the optimal design of MV repair procedure with better performance and durability.

We are also extending these in two directions. First, we are extending these studies to cellular deformation to link with the underlying mechanobiological responses of the constituent cellular population. Second, we seek to incorporate the entire MV model into a ventricular model, which is essential for the understanding of the underlying processes of ventricular, and MV coupled dysfunction. Other related projects on cardiac tissue remodeling and engineered tissue will be presented.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

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