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The heritability and prediction of complex human traits

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If you have a question about this talk, please contact Narinder Bansal.

The main focus of my lab is to understand the contribution of genetic and environmental factors to the aetiology of complex disease and medically related complex traits, as well as, to investigate how to best use these factors in the prediction of disease.

In the first part of the talk, I will present evidence that a part of the missing heritability can be explained by an overestimation of heritability due to shared familial environmental effects. In the second part, I will show that the use of a powerful statistical approach and large samples sizes provide considerable improvements of prediction accuracy of complex traits compared to typically used polygenic risk scores.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

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