Taking seriously the vectorial nature of metabolisms: implications for research in prebiotic systems chemistry

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• Kepa Ruiz-Mirazo (University of the Basque Country, Spain)
• Monday 20 April 2015, 14:00-15:00
• Seminar Room, Sanger Building, Department of Biochemistry.

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In this talk I will briefly introduce the concept of ‘vectorial metabolism’ and try to demonstrate its relevance not only in biology but also in the earliest stages of prebiotic evolution. Several protocell models, in vitro and in silico, will be discussed to illustrate how chemistry could be enhanced in the context of soft interfaces and lipid compartments.

References:

Murillo, S., Beaufils, D., González-Mañas, J.M, Pascal, R., Ruiz‐Mirazo, K. (2015): Increased peptide reaction yields in the presence of fatty acid aggregates – in preparation.

Shirt-Ediss, B., Solé, R.V. & Ruiz-Mirazo, K. (2015): Emergent chemical behavior in variable-volume protocells. Life 5(1): 181-211.

Ruiz-Mirazo, K., Briones, C. & de la Escosura, A. (2014): Prebiotic Systems Chemistry: New Perspectives for the Origins of Life. Chemical Reviews 114: 285-366.

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• Cambridge Infectious Diseases
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