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Tetrahydrobiopterin - Role in Ether Lipid Metabolism of Macrophages

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Tetrahydrobiopterin is an essential cofactor a set of metabolic reactions. It is well known for its role in the four aromatic amino acid hydroxylases (PAH) and three nitric oxide synthases (NOS). Recently we identified a gene coding for the integral membrane protein alkylglycerol monooxygenase, which catalyses a third destinct class of tetrahydrobiopterin-dependent reactions. The cytokine-regulation of the enzyme in macrophages provides a first glimpse on potential biological roles of this novel gene.

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