Self-organisation of pluripotent cells in the mouse embryo

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• Prof. Magdalena Zernicka-Goetz - Department of Physiology, Development and Neuroscience and Gurdon Institute
• Thursday 12 June 2014, 16:00-17:00
• Hodgkin Huxley Seminar Room, Physiology Building, Downing Site.

If you have a question about this talk, please contact Philipe Mendonca.

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The events at the time the mammalian embryo implants have been largely hidden from us – they take pace as embryos embed into the maternal tissues. To overcome this difficulty we have developed a culture system for embryos to permit their development at this stage outside the body of the mother and allows us to observe these events by time-lapse microscopy. This has revealed the first steps in how the pluripotent epiblast cells organise themselves into a structure that will develop into the foundation for the body. This requires cells to respond to signals from underlying basal membrane. Remarkably we can mimic this with a gel of extracellular matrix proteins and get ES cells to undertake the same self-organisation process. Just as a baby needs help to walk, so the epiblast needs the assistance of the flanking extra-embryonic tissues to guide its development and specify the body axes. Now we wish to understand precisely how these tissues interact to set the embryo on its correct developmental course.

This talk is part of the Foster Talks series.

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