Journal Club: Human-specific loss of regulatory DNA and the evolution of human-specific traits

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• Toomas Kivisild
• Thursday 05 May 2011, 13:00-14:00
• First Floor Seminar Room, Department of Zoology..

If you have a question about this talk, please contact Simon Baxter.

NATURE | VOL 471 | 10 MARCH 2011

http://www.nature.com/nature/journal/v471/n7337/abs/nature09774.html

Humans differ from other animals in many aspects of anatomy, physiology, and behaviour; however, the genotypic basis of most human-specific traits remains unknown1. Recent whole-genome comparisons have made it possible to identify genes with elevated rates of amino acid change or divergent expression in humans, and non-coding sequences with accelerated base pair changes2, 3, 4, 5. Regulatory alterations may be particularly likely to produce phenotypic effects while preserving viability, and are known to underlie interesting evolutionary differences in other species6, 7, 8. Here we identify molecular events particularly likely to produce significant regulatory changes in humans: complete deletion of sequences otherwise highly conserved between chimpanzees and other mammals. We confirm 510 such deletions in humans, which fall almost exclusively in non-coding regions and are enriched near genes involved in steroid hormone signalling and neural function. One deletion removes a sensory vibrissae and penile spine enhancer from the human androgen receptor (AR) gene, a molecular change correlated with anatomical loss of androgen-dependent sensory vibrissae and penile spines in the human lineage9, 10. Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA -damage-inducible, gamma (GADD45G)11, 12, a loss correlated with expansion of specific brain regions in humans. Deletions of tissue-specific enhancers may thus accompany both loss and gain traits in the human lineage, and provide specific examples of the kinds of regulatory alterations6, 7, 8 and inactivation events13 long proposed to have an important role in human evolutionary divergence.

This talk is part of the Cambridge Evolutionary Genetics series.

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• Cambridge Evolutionary Genetics
• First Floor Seminar Room, Department of Zoology.

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