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Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation

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Christov CP, Trivier E, Krude T. Br J Cancer. 2008 Mar 11;98(5):981-8. Epub 2008 Feb 19.

Abstract Noncoding Y RN As have recently been identified as essential factors for chromosomal DNA replication in human cell nuclei. Here, we investigate the expression of human Y RN As in tumours and test their requirement for cell proliferation. Relative expression levels of all four human Y RN As (hY1, hY3, hY4 and hY5 RNA ) were determined by quantitative RT-PCR in extracts from human solid tumours, corresponding nonmalignant normal tissues and derived cultured cells. On average, all four hY RNAs are significantly overexpressed in solid tumours between 4- and 13-fold, compared to the corresponding normal tissues. In particular, hY1 and hY3 RNAs are overexpressed in carcinomas (and adenocarcinomas) of the bladder, cervix, colon, kidney, lung and prostate with extremely high statistical significance (ANOVA, between groups, P

This talk is part of the CRI Reading Group on Cancer Systems Biology series.

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