m7G-tRNA in cancer: Molecular mechanism of resistance to METTL1 inhibition

Add to your list(s) Download to your calendar using vCal

• Helena Santos-Rosa Ruano (Miska Lab)
• Friday 23 May 2025, 15:00-16:00
• Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.

If you have a question about this talk, please contact reception.

N7-methylguanosine (m7G) modification of tRNAs is crucial for proper folding and stability of the cellular tRNA pool. It is catalyzed by METTL1 , a methyltransferase overexpressed in a large proportion of malignancies and a promising target for therapeutic purposes. Despite its critical role in cell proliferation, there is a substantial number of cancers insensitive to METTL1 inhibition and its genetic abrogation. Helena will present her progress towards the characterization of molecular pathways underlaying METTL1 resistance in human cancer cells.

This talk is part of the Biochemistry Friday Seminars series.

This talk is included in these lists:

• Cambridge Infectious Diseases
• Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road
• PMRFPS's
• Seminars at the Department of Biochemistry
• ndk22's list
• rc781
• se393's list

Note that ex-directory lists are not shown.