Advanced Microfluidic Platforms for Viscoelastic Fluid Dynamics and Biosensing

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• Amy Q. Shen, Micro/Bio/Nanofluidics Unit, OIST, Japan
• Thursday 27 March 2025, 14:00-15:00
• JDB Seminar RM.

If you have a question about this talk, please contact Anna Walczyk.

Microfluidics has revolutionized small-scale fluid manipulation, enabling precise control and visualization of complex flow dynamics to address challenges in biophysics, biotechnology, and healthcare. By combining advanced fabrication techniques with innovative sensing technologies, microfluidic systems facilitate real-time exploration of fluid dynamics and scalable biomedical applications. This talk presents recent advancements in microfluidic platforms, focusing on their role in investigating viscoelastic fluid instabilities and enhancing biosensing for diagnostics and personalized healthcare. 1. Viscoelastic Instabilities in Microfluidics: Using selective laser-induced etching (SLE), we developed glass microfluidic devices capable of sustaining high flow rates and real-time visualization of 3D viscoelastic instabilities. These platforms reveal synchronized motions and metachronal waves in viscoelastic flows, as well as the impact of geometric disorder on chaotic behaviors, offering insights for both industrial and biological applications. 2. Microfluidic Biosensing for Precision Diagnostics: Our lab-on-a-chip systems enable rapid and precise diagnostics. An optomicrofluidic device with localized surface plasmon resonance (LSPR) detects SARS -CoV-2 antibodies in plasma within 30 minutes at a detection limit of ~0.5 pM. Complementary electrochemical immunosensors distinguish infection-induced from vaccine-induced antibodies in under 7 minutes. Additionally, we developed platforms for detecting cancer biomarkers and bacteria using surface-imprinted polymers, providing scalable, non-invasive solutions for diagnostics and health monitoring.

This talk is part of the Engineering Fluids Group Seminar series.

This talk is included in these lists:

• Acoustics Lab Seminars
• Engineering Department Acoustics/Combustion Student seminars
• Engineering Fluids Group Seminar
• JDB Seminar RM

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