Probing Biomolecular Phase Separation Through Multiscale Computer Simulations

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• Pin Yu Chew, University of Cambridge
• Wednesday 26 February 2025, 14:30-15:00
• Unilever Lecture Theatre, Yusuf Hamied Department of Chemistry.

If you have a question about this talk, please contact Lisa Masters.

This talk has been canceled/deleted

Biomolecular condensates play crucial roles in cellular organisation, regulating diverse biological functions, as well as contributing to disease pathologies when phase separation is dysregulated. However, the physicochemical mechanisms by which they are formed and regulated are still not well understood, especially in the complex environment inside cells consisting of thousands of different components. Computer simulations have emerged as powerful tools to investigate phase transitions in these systems. In this talk, we will discuss how coarse-grained molecular-dynamics simulations at different resolutions can probe the molecular mechanisms governing biomolecular phase separation across different systems, as well as guide the design of proteins that can give rise to condensates with specific properties.

This talk is part of the Theory - Chemistry Research Interest Group series.

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