University of Cambridge > > External Seminars from the IMS-MRL (Institute of Metabolic Science-Metabolic Research Laboratories) > Compartmentalised metabolism and metabolite signalling to the nucleus

Compartmentalised metabolism and metabolite signalling to the nucleus

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  • UserDr Sophie Trefely, Signalling and Epigenetics, The Babraham Institute, Cambridge
  • ClockTuesday 14 February 2023, 13:15-14:15
  • Housein person & via zoom .

If you have a question about this talk, please contact Angela Lumsdon.

Intracellular metabolites act as powerful signalling cues to adjust cell behaviour to the nutrient environment. A variety of metabolites operate in the nucleus as substrates, co-factors, or inhibitors of chromatin-modifying enzymes and have emerged as key determinants of gene regulation. Given that cellular metabolism is highly compartmentalized, our understanding of pathways connecting nutrients to nuclear metabolites has been limited since standard metabolite analyses use whole cells. I will talk about my recent work on the development of novel approaches for sub-cellular metabolite analyses by mass spectrometry, with a focus on the acyl-Coenzyme A metabolite class. This work shows that the nucleus operates as a distinct metabolic compartment and marks an exciting step forward in understanding regulation of metabolism within the nucleus and how this links diet to the epigenome.

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This talk is part of the External Seminars from the IMS-MRL (Institute of Metabolic Science-Metabolic Research Laboratories) series.

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