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Towards whole-heart fluid-structural modelling

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The heart, great vessels and passing blood function as a dynamically interconnected whole. With a view to the modelling of medium to large scale whole-heart fluid-structural dynamics, this presentation aims to review and interpret the overall shape and inter-cavity dynamics of the heart, in exercising as well as resting states. After a brief review of the embryonic and presumed evolutionary origins of the four-chambered mammalian heart, several aspects of the form and function of the human heart and its adjoining large vessels will be illustrated using magnetic resonance acquisitions, ultrasound traces and other data:

- The forms, structures and dynamic relations of major components: blood, muscle, valves, vessels and pericardium. – Interrelations and differences between the right and left heart. – Atrio-ventricular coordination via the insulation-conduction system – Structurally and fluidically mediated veno-atrio-ventriculo-arterial coupling. – Changes of contractility, timings and flows with exercise. – The momentum changes of blood and the associated directional exchanges of force.

The presentation will conclude with a look towards the potential scientific and clinical value of whole-heart numerical modelling.

This talk is part of the Isaac Newton Institute Seminar Series series.

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