University of Cambridge > > Cellular and Molecular Pathology Seminars > The ins and outs of cellular quiescence

The ins and outs of cellular quiescence

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The majority of cells in the adult body are not proliferating and a fraction of these cells are quiescent. Quiescence is a state of reversible cell cycle arrest, from which cells can be stimulated to re-enter the cell cycle. During tissue maintenance and repair, the transition from quiescence to proliferation and proliferation to quiescence must be carefully regulated to maintain tissue size and function. Aberrant regulation of these cell cycle control mechanisms can drive the continuous proliferation of cells, promoting tumorigenesis. Our aim is to understand how cells enter, maintain and exit quiescent states. We investigate how these systems are controlled in non-transformed human cells and how quiescence in cancer cells may provide tumour cells with a survival advantage. To answer our questions, we use a combination of quantitative single-cell timelapse imaging, gene-editing, modelling, bioinformatics, screening and proteomics. This combined approach allows us to gain a systems-level understanding of transitions into and out of quiescence, while challenging long-held assumptions about cell cycle control. I will present recent data from the lab showing how cell size can influence the proliferative potential of quiescent cells and how modelling is providing us with a revised and more accurate view of cell cycle entry.

This talk is part of the Cellular and Molecular Pathology Seminars series.

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