Cell death as an antimicrobial mechanism against extracellular bacterial infection

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• Assistant Professor Chen Kaiwen, National University of Singapore. Hosted by Professor Clare Bryant.
• Wednesday 05 October 2022, 16:00-17:00
• Hybrid meeting, Jeffrey Cheah Biomedical Centre Lecture Theatre and Via Zoom, for more details go to https://www.immunology.cam.ac.uk/.

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Programmed necrosis including pyroptosis and necroptosis promote host resistance against infection as it destroys the replicative niche of intracellular pathogens. In contrast, whether and how necrotic cell death drives antimicrobial defence against extracellular pathogens is less defined. To address these questions, we examined innate immune and cell death signalling upon challenge with two enteric extracellular pathogens: Yersinia pseudotuberculosis and Citrobacter rodentium. Here, we demonstrate that Y. pseudotuberculosis and C. rodentium triggers apoptotic caspase activation, which cleaves the family of gasdermin proteins to trigger pyroptosis and host defence in vivo. We further show that differential inhibition of NF-kB signalling by extracellular pathogens dictate whether myeloid cells undergo pyroptosis or necroptosis.

This talk is part of the Immunology and Medicine Seminars series.

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