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Distributed brain network activities in memory resilient to extinction

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Abstract: Certain memories, including those of drug experience, overcome their extinction to invigorate unwanted behaviours. These powerful memories engage many brain regions; however, whether these regional activities are collectively organized for robust expression remains unknown. In this seminar, I will present ongoing work revealing the oscillatory structure and anatomical pathway of a neural pattern that stitches together brain-distributed activities in extinction-resilient retrieval of cocaine-paired memory. Binding together distributed brain networks in this temporally-structured manner may constitute an organizational principle of maladaptive memories.

This talk is part of the Zangwill Club series.

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