Mechanically-instructive Scaffolds to Steer Tissue Regeneration: Merging Mechaniobiology with Biofabrication

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• Prof Lorenzo Moroni, MERLN Institute for Technology-Inspired Regenerative Medicine, Complex Tissue Regeneration department
• Friday 11 March 2022, 14:00-15:00
• CUED LR5.

If you have a question about this talk, please contact Sara Seddon.

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Organs are complex systems, comprised of different tissues, proteins, and cells, which communicate to orchestrate a myriad of functions in our bodies. Technologies are needed to replicate these structures towards the development of new therapies for tissue and organ repair, as well as for 3D in vitro models to better understand the morphogenetic biological processes that drive organogenesis. To construct tissues and organs, biofabrication strategies are being developed to impart spatiotemporal control over cell-cell and cell-extracellular matrix communication, often through control over cell and material deposition and placement. To achieve these targets, the spatiotemporal control over biological signals at the interface between cells and materials is often aimed for. Alternatively, biological activity can be triggered through the control of mechanical cues, harnessing more fundamental know-how in mechanobiology that could be combined with biofabrication strategies. Here, I present some of our most recent advancements in merging mechanobiology with biofabrication that enabled the control of cell activity, moving towards enhanced tissue regeneration as well as the possibility to create more complex 3D in vitro models to study biological processes.

This talk is part of the Engineering - Mechanics and Materials Seminar Series series.

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