University of Cambridge > Talks.cam > PDG Seminars (Pathogen Dynamics Group) > Correlates of protection of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infections

Correlates of protection of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infections

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: Understanding the relationship between immune response to SARS -CoV-2 vaccines and protection against clinical outcomes is urgently needed to facilitate further vaccine development. However, evidence on correlates of protection from SARS -CoV-2 vaccine trials is limited. Using phase II/III ChAdOx1 nCoV-19 vaccine trial data in the UK, we estimated the correlates of protection by immune markers against symptomatic COVID -19 disease using a case-cohort study design. Our preliminary analysis found higher immune marker levels are associated with lower risk of symptomatic disease and in particular lower risk of lower respiratory tract infections.

This talk is part of the PDG Seminars (Pathogen Dynamics Group) series.

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