Seminar – Longitudinal growth modeling: a tool for genetic discovery

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• Dr Diana Cousminer, Children’s Hospital of Philadelphia, University of Philadelphia
• Friday 15 February 2019, 13:30-14:30
• Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP.

If you have a question about this talk, please contact Paul Browne.

Distinct growth patterns during adolescence correlate with adverse health outcomes such as poor cardiometabolic health and risk for osteoporosis, but the genetic mechanisms mediating differences in growth trajectories remain largely unknown. Longitudinal modeling using SuperImposition by Translation and Rotation (SITAR) breaks down complex growth trajectories into three components, “size”, “timing”, and “velocity.” We utilize these parameters as phenotypes for input into genome-wide association studies (GWAS), to better understand the genetic determinants of increase in bone mineral density at distinct skeletal sites and height growth.

This talk is part of the MRC Epidemiology and CEDAR Seminars series.

This talk is included in these lists:

• Annual Food Agenda
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Cambridge Global Food Security
• Cardiovascular Epidemiology Unit Special Seminars
• Department of Public Health and Primary Care
• MRC Epidemiology and CEDAR Seminars
• Primary Care
• Public Health talks
• PublicHealth@Cambridge
• Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP
• Talks related to sustainability and the environment
• history
• primary care

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