University of Cambridge > > What's on in Plant Sciences > A DNA methylation reader complex that enhances gene transcription

A DNA methylation reader complex that enhances gene transcription

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact david baulcombe.

DNA methylation generally functions as a repressive transcriptional signal but is also known to activate gene expression. In either case, the downstream factors remain largely unknown. Here, using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA . Two SU(VAR)3-9 homologues, the transcriptional anti-silencing factor SUVH1 , and SUVH3 , were among the methyl-reader candidates. SUVH1 and SUVH3 bound methylated DNA in vitro, were associated with euchromatic methylation in vivo, and formed acomplex with two DNAJ domain containing homologues, DNAJ1 and DNAJ2 . Ectopic recruitment of DNAJ1 enhanced gene transcription in plants, yeast and mammals. Thus, the SUVH proteins bind to methylated DNA and recruit the DNAJ proteins to enhance proximal gene expression, thereby counteracting the repressive effects of transposon insertion near genes.

This talk is part of the What's on in Plant Sciences series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity