Sequential Neurogenesis Establishes the Different Sensory Modalities of the Trigeminal Ganglia

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• Sophie Caron, Department of Molecular and Cellular Biology, Harvard University
• Wednesday 03 October 2007, 11:00-12:00
• Basement Seminar Room, Department of Zoology.

If you have a question about this talk, please contact Greg Jefferis.

PLEASE NOTE CORRECTED DATE - WED 3rd

Sensory ganglia are nerve centers containing neurons with different sensory modalities. How this cellular diversity is generated remains largely unknown. We addressed this question using the zebrafish trigeminal sensory ganglia as a model system. We found that the trigeminal ganglia are composed of early-born and late-born neurons. A specific subpopulation, defined by the expression of the channel trpA1b, only forms during early periods of neurogenesis. When we manipulated the trigeminal ganglia such that they are solely formed from late-born neurons, the trpA1b expressing neurons are absent. Consequently, such embryos are insensitive to mustard oil, a pungent chemical detected by TrpA1b, but respond to touch. Our results indicate that timing of neurogenesis underlies the diversification of sensory neurons.

This talk is part of the MRC LMB Neurobiology Seminars series.

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