University of Cambridge > Talks.cam > MRC Epidemiology and CEDAR Seminars > Early Life Undernutrition Alters Cardiac Muscle Development Resulting in Reduced Physical Activity Engagement and Increased Risk of Cardiovascular Disease

Early Life Undernutrition Alters Cardiac Muscle Development Resulting in Reduced Physical Activity Engagement and Increased Risk of Cardiovascular Disease

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Adults who were born with low birth weight are at increased risk of developing cardiovascular disease in adulthood. However, little is known about the contribution of cardiac mechanisms to this increased disease risk. Using a mouse model we evaluated cardiovascular function at the whole animal, organ, and cell level to determine the effect of a short episode of nutritionally-induced growth retardation on adult functional capacity following nutritional rehabilitation. Interestingly, mice that were undernourished development presented with reduced physical activity level engagement, impaired exercise capacity, and impairment in contraction mechanics of the heart. This phenotype is hypothesized to be due to alterations in the calcium kinetics of the contracting cardiomyocytes.

This talk is part of the MRC Epidemiology and CEDAR Seminars series.

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