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Linking Mammary Development and Breast Cancer

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Abstract: My group uses genetic approaches to study the intertwined roles of both Wnt and Hedgehog signaling in cell-fate decisions and amplification of stem and progenitor cell populations during embryonic and post-natal mammary development. We also investigate how these functions are linked to tumor onset and progression in adult mice. In an effort to identify further lineage markers with better prognostic utility for breast cancer subtypes we have begun to investigate a novel Adhesion-G-protein coupled receptor and a TGFbeta-binding protein, which identify early mammary stem/progenitors cells and specific luminal subpopulations respectively.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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