University of Cambridge > Talks.cam > Meeting the Challenge of Healthy Ageing in the 21st Century > Understanding age-related changes in tendon: a pathway to maintaining health into old age

Understanding age-related changes in tendon: a pathway to maintaining health into old age

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The recognition that the promotion of physical activity has one of the greatest potentials to achieve gains in health in older age highlights the importance of musculoskeletal fitness. However tendons, a key component of the musculoskeletal system, are particularly susceptible to age-related tendon dysfunction and disease. Our research has focused on understanding the mechanisms of age-related functional decline in tendon. This presentation will cover age-related changes to the mechanical properties of tendon and tendon sub-structures, changes to cell metabolism and the formation of advanced glycation end-product (AGE) crosslinks within the extracellular matrix of tendon.

This talk is part of the Meeting the Challenge of Healthy Ageing in the 21st Century series.

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