University of Cambridge > > Bacteriophage 2017 > Lambda Display Phage as a Mucosal Vaccine Delivery Vehicle for Peptide Antigens

Lambda Display Phage as a Mucosal Vaccine Delivery Vehicle for Peptide Antigens

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  • UserProfessor Sidney Hayes and Dr Philip J. Griebel, University of Saskatchewan, Saskatoon, Canada
  • ClockThursday 19 January 2017, 15:45-16:15
  • HouseOnline.

If you have a question about this talk, please contact Ilana Spilka.

There is increasing interest in using bacteriophage as protein/peptide and DNA vaccine delivery vehicles. Little isn known, however, about their capacity to induce mucosal immune responses in the small intestine. Targetted delivery of of lambda phage (LP) to specific sites in the small intestine of newborn calves confirmed LP were immunpgenic and we re specifically taken up by mucosa-associated lymphoid tissues, including Peyer’s patches. A lambda display phage (LDP) was then used to confirm that specific IgA antibody responses were induced to the display peptide. This specific antibody response was observed in the absence of an adjuvant or exogenous immune stimulating compound. Therefore, we conclude that LDP may be used as oral vaccine delivery vehicle.

This talk is part of the Bacteriophage 2017 series.

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