University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > Woofing it down – lessons on the neurobiology of appetite from man’s best friend

Woofing it down – lessons on the neurobiology of appetite from man’s best friend

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Obesity is a big problem in dogs and humans. We have exploited the unusual genetic architecture within dog breeds to discover a mutation in the gene POMC in Labrador dogs which predisposes them to obesity and high food motivation. The mutation prevents production of a neuroactive peptide which is important in humans but has previously been difficult to study because it is not produced by rodents. Ongoing studies are examining the role of POMC in energy homeostasis and investigating further genetic causes for breed-related differences in obesity susceptibility.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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