COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |
University of Cambridge > Talks.cam > Plant Sciences Departmental Seminars > RNA viruses: comparative genomics and gene expression mechanisms
RNA viruses: comparative genomics and gene expression mechanismsAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact sb771. RNA viruses have compact multifunctional genomes. During the course of infection, the genome or its derivatives must direct translation of virus proteins, genome replication and genome packaging. To realize these multiple roles, RNA virus genomes commonly have many overlapping coding and non-coding functional elements. Overlapping functional elements have often escaped detection because it can be difficult to disentangle the multiple roles of the constituent nucleotides via, for example, mutational analysis. On the other hand, RNA viruses evolve very rapidly and there are many sequenced isolates, thus providing potential for powerful comparative genomic analyses, even within single virus species. We have been using comparative genomics to systematically identify ‘hidden’ functional elements in RNA virus genomes. Computationally identified features can then be efficiently targeted for experimental analysis. We are particularly interested in characterizing unusual translation mechanisms – such as ribosomal frameshifting, stop codon readthrough, non-AUG initiation and IRES -mediated initiation – that are so frequently used by RNA viruses for gene expression. Recent work has focused on the atypical programmed ribosomal frameshifting mechanisms utilized by the arteriviruses and the cardioviruses, and RNA polymerase slippage in the potyviruses. To further understand these mechanisms, we have also employed the emerging technique of Ribosome Profiling. This talk is part of the Plant Sciences Departmental Seminars series. This talk is included in these lists:
Note that ex-directory lists are not shown. |
Other listsCJCR Effective Altruism: Cambridge Type the title of a new list here 6th Annual Cambridge Technology Ventures Conference - June 11th All Cavendish Laboratory Seminars Cambridge Society for Economic PluralismOther talksThe Galactic Centre: a template for understanding star formation and feedback in a high-pressure environment Connecting behavioural and neural levels of analysis Cambridge - Corporate Finance Theory Symposium September 2018 - Day 2 Religion, revelry and resistance in Jacobean Lancashire Political Thought, Time and History: An International Conference What has Engineering Design to say about Healthcare Improvement? |