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Activation and differentiation of human ILC3

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Chiara Romagnani, hosted by Francesco Colucci

Group 3 innate lymphoid cells (ILC3) are defined by the expression of ROR γt, which is selectively required for their development. ILC3 produce IL-22 and other pro-inflammatory cytokines and contribute to the defense against extracellular bacteria and Candida sp. Here we will discuss our findings on the characterization of human ILC3 and the signals driving their activation and differentiation. Moreover, we will discuss the recent identification of the lineage-specified progenitor cells of human ROR γt+ ILC3 and their developmental site after birth remain.

This talk is part of the Immunology and Medicine Seminars series.

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