Understanding Mechanisms of Sterile Inflammation

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• Dr David Brough, Faculty of Life Sciences, University of Manchester
• Wednesday 12 November 2014, 16:15-17:15
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Inflammation is an essential host response to infection and injury. At the heart of inflammation research is an attempt to understand the regulation of the pro-inflammatory cytokine interleukin-1β (IL-1β), which is central to host responses to infection, but also causes tissue injury when activated inappropriately. IL-1β is produced by many cell types as an inactive precursor (pro-IL-1β) and requires processing by the protease caspase-1 to obtain full biological activity. Caspase-1 is also produced as a precursor and becomes activated following recruitment to an intracellular multi-molecular scaffold called an inflammasome. Multiple inflammasomes are described, each defined by the presence of a cytosolic pattern recognition receptor (PRR). The PRR NLRP3 forms an inflammasome that drives the inflammatory response to pathogens such as Staphylococcus aureus or Listeria monocytogenes, but is also known to drive damaging inflammation during sterile inflammatory insults. The goal of my research is to understand the mechanisms regulating the production of IL-1 and how they contribute to disease.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 2, Department of Veterinary Medicine
• Vet School Seminars

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