University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > Understanding and manipulating CNS remyelination - in mouse, man and zebrafish.

Understanding and manipulating CNS remyelination - in mouse, man and zebrafish.

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Central nervous system (CNS) remyelination is inefficient in man, restricting recovery from demyelinating diseases such as multiple sclerosis. Post mortem MS tissue gives us a limited window into the mechanism of this, but means that we need to use other animal models. Rodent CNS remyelination is more efficient, especially in young rodents, with virtually complete remyelination in extent, though the myelin sheaths remain thin and short. These rodent models can be manipulated to change the efficiency of remyelination, allowing identification of potential therapeutic targets but also perhaps modelling human disease better. Zebrafish are generally very regenerative organisms, and I will discuss how efficiently they carry out CNS remyelination, and what differences between zebrafish, rodent and human may teach us about remyelination biology.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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