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Intrabodies for Huntington's and Parkinson's disease therapeutics

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Accumulation of misfolded proteins characterizes several important neurodegenerative diseases, including Huntington’s and Parkinson’s. The specificity and engineering potential of antibody fragments offers multifunctional approaches to modify the toxic effects of such proteins. By targeting the proteins intracellularly, intervention can occur at the earliest stage in a pathogenic cascade. Huntington’s offers particularly robust models and the can serve as a paradigm for related disorders.

This talk is part of the Cambridge Neuroscience Seminars series.

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