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Epigenetic Regulatory Complexes in Development and Cancer

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If you have a question about this talk, please contact Dr Ireena Dutta.

Epigenetic regulatory factors, including enzymes and chromatin binding proteins, have been implicated in virtually every step of tumor progression and the majority of cancer sub-types. Identification of the complexes in which these regulators function has yielded insights into their mechanisms and the biological/cancer processes they regulate. My research has focused primarily on the purification and characterization of complexes of the epigenetic regulators SIRT1 and CDYL , uncovering epigenetic mechanisms in Notch pathway regulation and suppression of oncogenic transformation respectively.

This talk is part of the MRC Cancer Unit Seminars series.

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