Repeat Proteins:Versatile frameworks for understanding and engineering protein structure and function

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• Lynne Regan, Yale University
• Monday 21 March 2011, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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Repeat proteins, such as TPR , ANK, LRR are prevalent in all organisms. Typically, their function is to mediate protein-protein interactions and to facilitate the assembly of multi-protein complexes. The simple, modular architecture of such proteins makes them ideal systems in which to investigate fundamental issues of protein stability and folding. For the same reasons, they are well suited to be used as frameworks for the design of novel proteins. I will present the results of our work on TPR proteins, including both fundamental studies of the structure and stability of this class of proteins, and the differences between them and globular protein, and the design of new TPR modules with a host of novel activities and applications.

This talk is part of the MRC LMB Seminar Series series.

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